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PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 438-450 doi: 10.1007/s11684-018-0674-4

Abstract: Cervical cancer (CC) is the fourth most commonly diagnosed female malignancy and a leading cause of cancer-related

Keywords： PD-1     PD-L1     immune checkpoint blockade antibody     immunotherapy     cervical cancer    

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Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervicalcancer: a randomized, non-inferiority, multicenter trial

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 93-104 doi: 10.1007/s11684-021-0892-z

Abstract: chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervicalcancer having risk factors after surgery.adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervicalcancer having pathological risk factors.

Keywords： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 264-270 doi: 10.1007/s11684-010-0094-6

Abstract: Cervical lesions have been regarded as the common and frequently occurring diseases in China.Recently, the morbidity and youth tendency of cervical cancer have gradually increased.Cervical cancer, related with human papilloma virus (HPV) infection, has been one of the severest diseasesThe well-known risk factors of HPV infection in cervical lesions consist of high-risk sexual behaviorsintraepithelial neoplasia (CIN), and cervical cancer.

Keywords： cervical lesion     high risk-human papilloma virus     persistent infection     loading dose     cervical intraepithelialneoplasia     cervical cancer    

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Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervicalcancer

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 106-112 doi: 10.1007/s11684-014-0307-5

Abstract:

Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasisHowever, the molecular alterations that drive progression and metastasis of cervical cancer remain unclearCellular senescence has been proposed as the mechanism that protects an organism against cancer progressionOur results suggested that the expression of Twist increased during the progression and metastasis of cervicalcancer.

Keywords： cervical cancer     senescence     Twist     CBX3     lymph node metastasis    

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Analysis of the results of cervical cancer screening for 49 384 rural women in Hetian District，Xinjiang

Wang Ying,Wang Xiaoli and Mi·Siriergeleng

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 96-98

Abstract:

To analysis the results of cervical cancer screening for rural womenThe research provided epidemical instigation of cervical cancer and clinic service for local women byThe prevalence rate of cervical cancer and precancerosis is 0.09 %，early diagnosis rate is 86.05 %.

Keywords： cervical cancer     Xinjiang     gynaecologicaldisease    

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relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis in cervicalcancer

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 447-451 doi: 10.1007/s11684-009-0082-x

Abstract: to evaluate the relationship between PDGF expression and stages and metastasis of cervical cancer.At the early stage of cervical cancer, BVD and LVD were significantly higher than in the controls (<The BVD and LVD in tissues in the surrounding areas of cervical cancer were significantly higher thanBVD and LVD were not associated with the differentiation and pathological stages of cervical cancer.of cervical cancer.

Keywords： cervical cancer     lymphatic vessel density     blood vessel density     platelet-derived growth factor    

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Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 459-462 doi: 10.1007/s11684-009-0084-8

Abstract: intraepithelial neoplasia (CIN) or cervical cancer, in order to provide a basis for cervical cancercolposcopy for screening CIN or cervical cancer.The prevalence of HPV and cervical precancerous lesions or cervical cancer was evaluated in differentIn addition, the CIN and cervical cancer detection rate of the 22―29-year-old age group (0.34%)The prevention and treatment of cervical cancer should be focused on those women more than 35 years of

Keywords： cervical cancer     human papilloma virus     cervical intraepithelial neoplasia    

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Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 341-346 doi: 10.1007/s11684-009-0067-9

Abstract: was to investigate the regulation of proliferation and apoptosis by LY294002, an inhibitor of PI3K in cervicalcancer cells and the expression of FLICE-like inhibitory protein (c-FLIP) .Human cervical cancer HeLa cells were used in this experiment and cultured.cancer cells.Moreover, the regulation of c-FLIP expression through PI3K/Akt signal pathway in cervical cancer cells

Keywords： human cervical cancer cells     apoptosis     phosphatidylinositol 3-kinase (PI3K)/Akt     FLICE-like inhibitory    

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HPV prevalence and genotyping in the cervix of Chinese women

Shao-Ming WANG, Jing LI, You-Lin QIAO

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 259-263 doi: 10.1007/s11684-010-0095-5

Abstract: The role of human papillomavirus (HPV) as an etiologic factor of cervical cancer has been firmly establishedVaccination implies a promising future for cervical cancer prevention especially for countries with veryof most recent years, and aims to draw a definitive conclusion on HPV prevalence and genotyping in cervicalcancer and precancerous lesions in China from the aspect of study population, geographic areas and time

Keywords： human papillomavirus (HPV) genotyping     cervical cancer     precancerous lesions     Chinese women    

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Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlled trial

Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 112-116 doi: 10.1007/s11684-010-0016-7

Abstract: influence of closure or nonclosure of the peritoneum and subcutaneous tissue on the clinical outcomes of cervicalcancer patients who underwent radical hysterectomy with lower abdominal cross incision.This randomized controlled trial was performed on 158 cervical cancer patients in our hospital between

Keywords： cervical cancer     radical surgery     peritoneum     subcutaneous tissue    

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A new thinprep cytologic test of cervical cells and its application

Xiaojun ZHAO, Jingjuan WEI, Rong WANG, Yajun GU, Yunde LIU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 227-229 doi: 10.1007/s11684-009-0035-4

Abstract: In order to improve the quality of routine cervical smears, we investigated the new Thinprep cytologictest (TCT) for cervical cells.In one group, the TCT for cervical cells was applied (TCT group), and in the other group routine cervicalthe TCT was superior to the routine cervical smear.Meanwhile, in comparison to the routine cervical smear, the TCT for cervical cells has 5 advantages which

Keywords： thinprep cytologic test     cervical cells     Papanicolaou smear    

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Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin

Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 223-228 doi: 10.1007/s11684-017-0517-8

Abstract:

The objective of this study is to guide a triage for the management of cervical high-grade squamouspatients presented residual HSIL in their subsequent surgical specimens, including 4 cases of invasive cervical

Keywords： cervical high-grade squamous intraepithelial lesion     conization     positive surgical margin     hysterectomy    

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Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

Chengwei JING, Qin FU, Xiaojun XU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 45-48 doi: 10.1007/s11684-009-0019-4

Abstract: This study was aimed to explore the anterior cervical surgery methods to treat central cord syndromeCCSWORFD), retrospectively analyze the cases of CCSWORFD, and evaluate the curative effect of anterior cervicalTwenty four cases of CCSWORFD (19 males and 5 females), all suffering from cervical hyperextension injury, between 45-68 (average 59) years old, were operated on by anterior cervical surgery methods.improved scores of cases with iliac bone grafting, = 3.270, <0.05), and reliable reconstruction of cervical

Keywords： central cord syndrome     decompression     surgical     titanium mesh    

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Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen

WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 177-180 doi: 10.1007/s11684-007-0033-3

Abstract: The aim of the present research is to study the mechanism of cervical nerve compression syndrome of theexternal intervertebral foramen and its differential diagnosis with cervical spondylosis.The etiology of cervical nerve compression syndrome of the external intervertebral foramen lies in thecompression of the cervical plexus, brachial plexus and cervical dorsal rami by the tendinous decussatingintervertebral foramen from cervical spondylosis.

Keywords： satisfactory     COX     minimus     operation     compression syndrome    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Title Author Date Type Operation

PD-1/PD-L1 blockade in cervical cancer: current studies and perspectives

Yumeng Wang, Guiling Li

Journal Article

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervicalcancer: a randomized, non-inferiority, multicenter trial

Journal Article

Clinical significance of human papilloma virus infection in the cervical lesions

Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA

Journal Article

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervicalcancer

Tian Wang, Yan Li, Abidan Tuerhanjiang, Wenwen Wang, Zhangying Wu, Ming Yuan, Shixuan Wang

Journal Article

Analysis of the results of cervical cancer screening for 49 384 rural women in Hetian District，Xinjiang

Wang Ying,Wang Xiaoli and Mi·Siriergeleng

Journal Article

relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis in cervicalcancer

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Journal Article

Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

Journal Article

Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Journal Article

HPV prevalence and genotyping in the cervix of Chinese women

Shao-Ming WANG, Jing LI, You-Lin QIAO

Journal Article

Non-closure of the peritoneum and subcutaneous tissue at radical hysterectomy: A randomized controlled trial

Zhou-Fang XIONG MD, Wei-Hong DONG MD, Ze-Hua WANG MD,

Journal Article

A new thinprep cytologic test of cervical cells and its application

Xiaojun ZHAO, Jingjuan WEI, Rong WANG, Yajun GU, Yunde LIU

Journal Article

Triage for management of cervical high-grade squamous intraepithelial lesion patients with positive margin

Yuya Dou, Xiaodan Zhang, Yang Li, Fenfen Wang, Xing Xie, Xinyu Wang

Journal Article

Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

Chengwei JING, Qin FU, Xiaojun XU

Journal Article

Differential diagnosis of cervical nerve compression syndrome of the external intervertebral foramen

WANG Jinwu, NI Weifeng, XU Jianguang, ZHU Haibo, GUO Shangchun, ZENG Bingfang, ZHAO Binghui

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article